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1

Quest for a COVID-19 Cure by Repurposing Small Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply

De Savi, Chris, Hughes, David L, Kvaerno, Lisbet

Journal:

Organic Process Research & Development

Year:

2020

File:

PDF, 1.24 MB

2020

2

ChemInform Abstract: Syntheses of the D-Aldopentoses from Non-Carbohydrate Sources.

Martin G. Banwell, Chris De Savi, David C. R. Hockless, Susanne Pallich, Keith G. Watson

Journal:

Year:

1999

File:

PDF, 30 KB

1999

3

ChemInform Abstract: Total Synthesis of the Microtubule-Stabilizing Agent (-)-Laulimalide (I).

Ian Paterson, Chris De Savi, Matthew Tudge

Journal:

Year:

2002

File:

PDF, 24 KB

2002

4

ChemInform Abstract: Construction of Perhydro Indol-2-ones by a Methoxide Catalyzed Deacetylation—Michael—Aldol Cascade.

John W. Ward, Karen Dodd, Caroline L. Rigby, Chris De Savi, Darren J. Dixon

Journal:

Year:

2010

File:

PDF, 31 KB

2010

5

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis

Chris De Savi, Andrew Pape, John G. Cumming, Attilla Ting, Peter D. Smith, Jeremy N. Burrows, Mark Mills, Chris Davies, Scott Lamont, David Milne, Calum Cook, Peter Moore, Yvonne Sawyer, Stefan Gerhar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 707 KB

english, 2011

6

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

Chris De Savi, Andrew Pape, Yvonne Sawyer, David Milne, Chris Davies, John G. Cumming, Attilla Ting, Scott Lamont, Peter D. Smith, Jonathon Tart, Ken Page, Peter Moore

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

7

Selective non zinc binding inhibitors of MMP13

Chris De Savi, Andrew D. Morley, Attilla Ting, Ian Nash, Kostas Karabelas, Christine M. Wood, Michael James, Stephen J. Norris, Galith Karoutchi, Neil Rankine, Gordon Hamlin, Philip A. MacFaul, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.65 MB

english, 2011

8

Elaboration of the side-chain of amino acid derivatives by palladium catalysed couplings

Geoffrey T. Crisp, Yu-Lin Jiang, Peter J. Pullman, Chris De Savi

Journal:

Year:

1997

Language:

english

File:

PDF, 653 KB

english, 1997

9

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Jung, Frédéric H., Pasquet, Georges, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques M., Warin, Nicolas, Renaud, Fabrice, Germain, Hervé, De Savi, Chris, Roberts, Nicola, Johnson, Trevor

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 513 KB

english, 2006

10

Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2

Chris De Savi, Andrew D. Morley, Ian Nash, Galith Karoutchi, Ken Page, Attilla Ting, Stefan Gerhardt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

11

Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Mortlock, Andrew A., Foote, Kevin M., Heron, Nicola M., Jung, Frédéric H., Pasquet, Georges, Lohmann, Jean-Jacques M., Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J., Johnson, Tre

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 182 KB

english, 2007

12

Total Synthesis of the Microtubule-Stabilizing Agent (−)-Laulimalide

Paterson, Ian, De Savi, Chris, Tudge, Matthew

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

13

Hydantoin based inhibitors of MMP13—Discovery of AZD6605

De Savi, Chris, Waterson, David, Pape, Andrew, Lamont, Scott, Hadley, Elma, Mills, Mark, Page, Ken M., Bowyer, Jonathan, Maciewicz, Rose A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

14

Efficacious Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD

De Savi, Chris, Cox, Rhona J., Warner, Daniel J., Cook, Anthony R., Dickinson, Mark R., McDonough, Amy, Morrill, Louis C., Parker, Beth, Andrews, Glen, Young, Simon S., Gilmour, Peter S., Riley, Rob,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 753 KB

english, 2014

15

First total synthesis of (+)-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) from a non-carbohydrate source

Banwell, Martin, Savi, Chris De, Savi, Chris De, Watson, Keith

Journal:

Chemical Communications

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

16

Synthesis of the Macrocyclic Core of Laulimalide

Paterson, Ian, Savi, Chris De, Tudge, Matthew

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 96 KB

english, 2001

17

Construction of perhydro indol-2-ones by a methoxide catalyzed deacetylation–Michael–aldol cascade

Ward, John W., Dodd, Karen, Rigby, Caroline L., De Savi, Chris, Dixon, Darren J.

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1022 KB

english, 2010

18

Diastereoselective synthesis of (−)-N-acetylneuraminic acid (Neu5Ac) from a non-carbohydrate source

Banwell, Martin, De Savi, Chris, Watson, Keith

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1998

Language:

english

File:

PDF, 87 KB

english, 1998

19

Diastereoselective routes to side-chain truncated analogues of N-acetylneuraminic acid†

Banwell, Martin, Savi, Chris De, Hockless, David, Watson, Keith

Journal:

Chemical Communications

Year:

1998

Language:

english

File:

PDF, 52 KB

english, 1998

20

Investigation of ( E )-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Degorce, Sébastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A., Peru, Aur

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.39 MB

english, 2015

21

Optimization of a novel binding motif to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist

De Savi, Chris, Bradbury, Robert H., Rabow, Alfred A., Norman, Richard A., de Almeida, Camila, Andrews, David M., Ballard, Peter, Buttar, David, Callis, Rowena, Currie, Gordon S, Davies, Christopher,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

22

Furan Diels-Alder Cycloaddition Approach to the Highly Oxygenated Core of Scyphostatin

Stevenson, Neil, De Savi, Chris, Harrity, Joseph

Journal:

Year:

2006

Language:

english

File:

PDF, 64 KB

english, 2006

23

Correction to Investigation of ( E )-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Degorce, Sébastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A., Peru, Aur

Journal:

Journal of Medicinal Chemistry

Year:

2016

File:

PDF, 132 KB

2016

24

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, Jeffrey G., McGuire, Thomas, Meadows, Rebecca E., Barlaam, Bernard, Clark, Jemma, Cook, Calum R., Davison, Gemma, Dishington, Allan, Savi, Chris De, Donald, Craig, Grebe, Tyler, Hande, Sudhir,

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 303 KB

english, 2016

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